Trialkylmethanobenzazocinols

ABSTRACT

1,2,3,4,5,6-Hexahydro-3-substituted 2,6,11-trialkyl-2,6methanobenzazocin-8-ols, analgetics and analgetic antagonists.

Uniie tates Patent Sallay 14 1 July 1, 1975 [54] TREALKYLMETHANOBENZAZOCINOLS 3,625,948 12/1971 Haberli .7 260/293.54 3,639,407 2/1972 Clarke et a1. 260/293.54 [75] Inventor: Stephen sanay Fort Wayne 3,647,806 3/1972 Cros s 260/293.54 73 Assigneez Purdue Research F d i W 3,700,734 10/1972 Robmson et a1. 260/293.54 Lafayette Ind. 3,764,606 10/1973 Akkerman et a1. 26()/293.54

[22] plied: 1973 Primary ExaminerG. Thomas Todd [21] Appl. N0.: 392,844 Attorney, Agent, or Firm.1ames L. Rowe; Everet F.

Smith [52] US. C1. 260/293.54; 260/590; 260/D1G. 13; 424/267 [51] Int. C1 C07d 39/00 [57] ABSTRACT [58] Field Of Search 260/293.54, DIG. 13 1,2,3,4,5 6-He ahydr0-3- ubstituted 2,6,1 l-trialkyl- 2,6-methanobenzazocin-8-015, analgetics and analgetic [56] References Cited antagonists.

UNITED STATES PATENTS 9 Cl N D 3,558,638 1/1971 Clarke et al. 260/294.3 'awmgs TRHALKYLMETI-IANOBENZAZOCINOLS BACKGROUND OF THE INVENTION May and Murphy, J. Org. Chem., 20, 257 1955) first achieved the synthesis of benzazocines (benzomorphans). (Y and P CH X, Z, and Q H in formula XX below.) The tricyclic system can be regarded as a simplified morphine structure.

/1 1 9 H -P a Z The compound had about one-half the analgesic activity of meperidine or of dromoran. In a continuation of this reasearch program, May, J. Org. Chem., 21, 899 (1956) prepared an N-phenylethyl analog (Y CH P CI-I CH C H X, and Z, and Q H in formula XX), yielding a compound with about one-third the analgesic activity of the corresponding N-methyl compound. In a further extension of this work, May and Fry, J. Org. Chem, 22, 1366 (1957) prepared compounds with a methyl group present on the endomethylene bridge (Y, Z, and P CH X and Q H in formula XX). The corresponding 8-hydroxy compound (Y, Z, and P CH X OH, O H in formula XX) was also prepared, and this latter compound was a potent analgesic with a relatively low toxicity. Eddy, Murphy and May disclosed a novel synthesis for compounds corresponding to XX wherein Y and P are CH Q is H and X is permissibly hydroxy, in J. Org. Chem., 22, 1370 (1957). Finally, May and Eddy in J. Org. C/1em., 24, 294 (1959) described two novel analgesic compounds in which, in formula XX, X OH, Y and Z CH Q H and P is either methyl or phenethyl. The compound in which P was methyl was resolved into d and l isomers with the levo isomer having an ED of 1.7 mg./kg. The corresponding phenethyl derivatives (P CH- CH C H on being resolved yielded a levo isomer and a dextro isomer both of which were analgesically active, the levo isomer being 20 times more potent than morphine. The dextro isomer had an ED,-,,, 6.7 mg/kg and manifested a low physical dependence. This latter compound is now a marketed analgesic with the generic name phenazocine. The above work is also described in U.S. Pat. No. 3,138,603, which claims compounds according to formula XX wherein X OH, Y and Z CH;,, and P H,CH or CH CH C H Q being H in all compounds. These same compounds were claimed by Gordon et al. in U.S. Pat. No. 2,959,594 but the claims were apparently lost in an interference between that patent and U.S. Pat. No. 3,138,603. Other Gordon patents include U.S. Pat. No. 2,924,603 which covers compounds of formula XX above wherein X OH, Y and Z CH Q H and P is a heterocyclic ethyl group such as pyridylethyl, thienylethyl, etc. and U.S. Pat. No. 3,033,867 in which nicotinyl esters of the compounds claimed by May in U.S. Pat. No.. 3,138,603 are described. Archer, U.S. Pat. No. 3,250,678, claims compounds according to formula XX above in which one of Y and Z is ethyl, the other being hydrogen, methyl or ethyl, X =OH, Q H and P lower alkenyl containing 3-6 carbon atoms, particularly allyl and 3-methyl-2- butenyl. The patent also covers the marketed compound pentazocine in which X OH, Y and Z C H Q H, and P 3-methyl-2-butenyl. A second Archer patent, U.S. Pat. No. 3,372,165, covers related compounds in which a cyclopropylmethyl side chain replaces the 3-methyl-2-butenyl of pentazocine (XX above wherein X OH, Y and Z CH Q H, and P cyclopropylmethyl).

None of the cited literature discloses a single compound in which 0 in formula XX is other than hydrogen. Furthermore, none of the syntheses described in the cited literature provides a synthetic procedure for the preparation of such a compound; in other words, the known synthetic procedures rely upon the absence during the ring closure reaction of any substituent group at the position to be occupied by Q in the benzazocine ring system before it is formed. Furthermore, there is no procedure known in the literature by which a substituent in Q-position could be introduced after the benzazocine ring-system is completed.

It is an object of this invention to provide 2- alkylbenzazocines active as analgesic substances and as analgesic antagonists.

SUMMARY OF THE INVENTION This invention provides benzazocines of the followalk alk

wherein each alk independently is C -C alkyl, R is H or alk and R is H, alk or wherein R iscyclopropyl or C -C alkenyl and R is hydrogen, methyl or ethyl, the sum of the carbon atoms in R plus R being less than 7. Also included within the scope of this invention are the pharmaceuticallyacceptacle acid addition salts of the bases represented by the above formula formed with non-toxic acids. These acid addition salts include salts derived from non-toxic inorganic acids including hydrochloric acid, nitric acid, phosphoric acid, sulfuric acid, hydrobromic acid, hydriodic acid and the like, as well as salts of nontoxic organic acids including acetic acid, maleic acid, fumaric acid, malic acid, succinic acid, tartaric acid, citric acid, benzoic acid, 2,4-dinitrobenzoic acid, pchlorobenzoic acid, naphthoic acid, p-toluenesulfonic acid, methanesulfonic acid and the like.

In the above formula, the term C -C alkyl includes methyl, ethyl, n-propyl; included in the term C -C,, alkenyl are the radicals vinyl, 1-propenyl, 2-propenyl, isobutenyl, 2-methyl-2-propeny1, l-butenyl, 2-butenyl, 3-butenyl, 2-methyl-l-butenyl, 2-methyl-2-butenyl,

3 2-methyl3-butenyl, 3-methyl-l-butenyl, 3-m'eth yl-2- butenyl, 3-methyl-3-butenyl, 2-ethyl-l-propenyl, 2-1

l-methyl-3-butenyl, l-methyl-l-propenyl, l-methyl-2 propenyl, l-ethyl-Z-propenyl, l-methyl-I-pentenyl, Z-methyl-l-pentenyl, 3-methyl-2-pentenyl, 4-methyl-3- pentenyl, 2-methyl-4-pentenyl and the like. Thus R and R when taken in conjunction withlthe carbon atom to which they are attached, form an unsaturated group including such well known groups as those having the following trivial or systematic names: allyl, methallyl, crotyl, 3-methyl-2-butenyl, 3-hexenyl,

2-methyl-2-propenyl and the like.

The compounds of this invention are solids, and are usually isolated and purified in the form of an acidaddition salt. The compounds are prepared by a multistep procedure whereby the tricyclic benzazocine ring structure containing the desired 2-alkyl substituents is built up from a tetralone to yield a compound of the above formula wherein R is H. The active analgetics and analgetic antagonists of this invention are prepared therefrom by standard alkylation procedures.

The compounds of this invention (I) are optically active in that each contains three asymmetric carbon atoms at positions 2, 6 and l l of the benzazocine ring, (see formula XX for numbering) yielding theoretically 8 diastereoisomers. However, since the methano bridge can only be cis fused, onehalf of the theoretical number of isomers are eliminated, leaving two pairs of diastereoisomers occurring as two racemates, the a-dl or less soluble racemate and the ,B-dl or more soluble racemate. Resolution of the racema te into its component i! :5 v red.

alk

and 1 isomers can be accomplished by salt formation with an optically active acid and separation of thedjastereoisomeric salt, by procedures well known .in the art.

In synthesizing the compounds of the present invention, a l-alkyl-7-alkoxy-2-tetralone (II) prepared by the procedure of Kuehne J. Am. Chem. 500., 83, 1492-8 (1961) is alkylated with an ally] halide such as the bromide or chloride to produce the corresponding l-alkyl-l-allyl-7-alkoxy-2-tetralone (III).

all 'lX alk allyl III Next, the Z-tetralone is transformed to a ,B-keto ester by carbalkoxylation procedure using a dialkyl carbonate such as dimethylcarbonate or diethylcarbonate as the carbalkoxylating agent. An added solvent such as tetrahydrofurane may optionally be present. The ,B-keto ester thus prepared (IV) can be alkylated using conventional procedures employed with other B-keto esters to provide V which, after hydrolysis and spontaneous decarboxylation, yields a 3-alkyl-2-tetralone (.V I).

The more roundabout procedure must be employed since direct alkylation of III provides a 3,3-dialkyl tetralone derivative.

Ozonoly'sis of the l-allyl group of the 2-tetralone (VI) followed by reductive cleavage of the ozonide quantitatively produces the tetralin 'y-keto aldehyde (VIII). Treatment of the keto aldehyde with a trace of alkali causes an intramolecular aldol condensation to take place, thus producing the tricyclic tetrahydro-5,8- methano-S-I-I-benzocyclohepten-lO-one-7-ol derivative (IX).

alk CHz-CHO .VIiI

The benzocycloheptenolone IX represents a diastereoisomeric pair with a cis and a trans hydroxyl at the C carbon (cis meaning that the hydroxyl is on the same side of the 7-membered ring as the methano bridge and trans meaning that the hydroxyl is on the opposite side of the 7-membered ring from the methano bridge.

Compound IX is the key intermediate fo'r 'the production of compounds represented. by formula I and the first step in the transformation of the benzocycloheptenolone (IX) to a compound of formula Iis the protection of the 7-hydroxyl group via ether formation, preferably with tetrahydropyranyl ether. The tetrahydropyranyloxy compound (X) is subjected to a Wittig reaction in which a triphenyl phosphoniurnmethylide in a solvent such as dimethylsulfoxide replaces the 10- keto group with a methylene group, yielding the exomethylenebenzobicycloheptenyl ether (XI) in quantitative yield. Removal of the 7-hydroxy group readily produces the exomethylene' ketone (XVI). The yield for the six step procedure (VI through XVI) is about 80 percent overall.

oxidation I If higher C -alkylidene derivativesare desired. for.

example, the ethylidene. or;n-propylid e,ne derivatives, the appropriate Wittig reagent is employed such as triphenyl phosphonium-ethylide I ,triphenyl phosphonium-n-prop ylide. I I

Next, the methylene'linleageofXVI is reduced to yield either a cis C -C dialkyl dias tereo isiomervor a trans C -C dialkyl diastereoisomer (XVII), depending on the reduction conditions employed. Reduction of the exomethylene ketone XVI with a pIatinurn-oncarbon catalyst yieldspredominantly the cis C C dialkyl diastereoisomer of 6,7,8,9-tetrahydro-5,8-dialkyllO-methyl-3 alkoxy-5,8 methano-(fl )-b enzocyclohepten-7-one. Reduction of the IO-ethylidene or propylidene derivatives yields the corresponding cis- IO-ethyl or cis-lO-propyl compound.

As an alternative procedure,'the corresponding pure trans isomer is prepared by a v stereoselective hydroboration-oxidation reaction on the exomethylene compound (XI) to form an.equatorially-oriented hydroxymethyl (methylol) group. The methylol hydroxyl is next esterified with p-toluenesulfonylchloride in pyridine. Hydride reduction of the tosyl ester followed by acid hydrolysis of the ethereal linkage-andoxida'tion of the C -hydroxyl yields directly the trans-C C dialkyl diastereoisomer of 6,7,8,9-tetrahydror5,8-dialkyl-l0; methyl-3-alkoxy-5,8-methano-(iI)-benzo,cycloheph en-7-one (XVII). Higher C -alkyl derivativeshaving a trans configuration are prepared in similar fashion. Both the cis and trans-C -C dialkyl'derivative s are represented by XVII. i

XVII

alk

NOTHP alk c-alfi =0 alk 5 alk xxx 65 The S-alkyl ether is then transformed to the corresponding hydroxy compound by treatment with pyridinium hydrochloride to yield the desired aminophenol starting material (I) wherein R and R H.

The above procedure can also be used to synthesize a benzazocine (XX) in which Y and Z CH;,, and X OH and Q and P H. Alkylation ofthis particular derivative on the N yields, among other compounds, pentazocine. In preparing compoundsin which Q is H (rather than alkyl as in applicants compound), the tetralone alkylation steps (lV -+Vl) can be obviated and (III) can be ozonized directly to yield a y-keto aldehyde which undergoes an intramolecular condensation to give a methano-bridged compound.

The analgetic compounds of this invention represented by l in which R is other than H are prepared by alkylating the secondary amine with an alkyl or alkenyl halide under basic conditions to yield compounds according to I wherein R is other than H. Alternatively, the secondary amine can be acylated as with an acyl halide and the corresponding amide reduced to an alkyl group with LiAlH, or the like.

This invention is further illustrated by the following specific examples.

EXAMPLE 1 3,4-Dihydro- 1 -methyl- 1 -allyl-7-methoxynaphthalen- 2( lg )-one A solution of 57.0 g. l-methyl-7-methoxy-2-tetralone prepared by the method of M. E. Kuehne, J. Am. Chem. Soc., 83, 1492-8, l96l in 50 ml. of dry tetrahydrofuran was slowly dropped into a suspension of 7.2 g. sodiumhydride in 200 ml. of dry tetrahydrofuran. The exothermic reaction was controlled by external cooling between 35-45C. After the hydrogen evolution subsided, the solution was cooled to about +C. and treated with 37.4 g. allylbromide. The temperature of the reaction was kept between 30-40C. After the addition of the allylbromide had been completed, the reaction mixture was stirred for about 12 hours at room temperature. NaBr, produced in the above reaction was separated by filtration and the reaction mixture was evaporated to dryness. The residue was dissolved in ether, the ether solution extracted with water, dried and evaporated in vacuo to an orange-colored oil. The residual oil was distilled in vacuo to yield 64.5 g. 3,4- dihydrol -methyl- 1 -allyl-7 -methoxy-naphthalen- 2( lLU-one distilling in the range 1 l9-l20C./,005 mm Hg. The IR spectrum exhibited bands at 3.27p.p.(- CH=CH- 5.86p.( C=O) and 6.02p.(HC=CH NMR (CDCl;,) showed chemical shifts at 51.40 (s, 3H C-CH 8 3.77[L(S, 3H, OCH;). and 8 5.20p.(m, 3H, CH=CH Analysis for C H O required: C, 78.23; H, 7.88%. Found: C. 78.12; H, 7.66%

Following the above procedure. but substituting l-ethyl-7-methoxy-2-tetralone for l-methyl-7- methoxy-2-tetralone, one obtains 3,4-dihydro-l-ethyl- 1-allyl-7-methoxy-naphthalen-2( l H)-one.

EXAMPLE 2 3 ,4-Dihydro- 1 -methyl- 1 -allyl-3-carbomethoxy-7- methoxy-naphthalen-2( l H )-one 62.0 g. of 3 ,4-dihydro- 1 -methyl- 1 -allyl-7- methoxynaphthalen-2-( lfl)-one prepared by the procedures of Example l,'was dropped into a suspension of 6.5 g. of sodium hydride in 250 ml. of dimethylcarbonate and the resulting mixture gently refluxed until hydrogen evolution had subsided. The reaction mixture was cooled, and diluted with ether. The ether layer was extracted with water, separated and dried. Distillation yielded 65.8 g. of 3,4-dihydro-l-methyl-l-allyl-3- 8 carbomethoxy-7,-methoxy-naphthalen-2( lfl)-one boiling in; the range l46l49C./0.0l mm. Hg. x,,,',',, 5.72 1; I (ester), 5.8312(ketone); 6.01 t c=c' coocH The product exhibited an intensive dark violet color with ferric chloride. I

EXAMPLE 4 3 ;4-Dihy dro-1,3-dimethyl-l-allyl-3-carbomethoxy-7- methoxy-naphthalen-2( lH)-one Procedure A.

A solution of 56.5 g. of 3,4-dihydro-l-methyl-l-allyl- 3-carbomethoxy-7-methoxy-naphthalen-2( lli)-one in about 50 ml. of tetrahydrofuran was slowly added to a stirred suspension of 4.7 g. sodium hydride in about 250 ml. tetrahydrofuran. The reaction temperature was kept between 2025C. After the hydrogen evolution had ceased, 42.0 g. methyliodide were added to the reaction mixture within a few minutes. The temperature was maintained between 3040C. After the exotherm'ic .reaction had subsided, "the reaction mixture was stirred at room temperature overnighL'Inorganic substafnce s'were filtered off, and the solvent was 'evapofrated in vacuo. The resulting oily residue was dissolved in ether, and the ether solution extracted with water, dried, filtered and evaporated in vacuo. The residual orange-yellow oil was distilled. 3,4-dihydro-l 3- dimethyll -allyl-3-carbomethoxy-7-methoxy naphthalen-2( ll;l)-one prepared by the above procedure boiled in the range l50C./0.0l mm Hg. Yield=55.0 g. The IR spectrum exhibited'bands at 3.2;L( C= CH 5.77;;(ester), 5 .85;;(ketone). Ferric chloride test was negative.'

Procedure B.

12.8 g. of 3,4'-dihydro-l-methyl-l-allyl-7-methoxynaph'thalen-2( lfl)-one was introduced into a suspen sion of'l .4 g. sodium hydride in about ml. of dimethylca'rbonate. The res ulting'mixture was gently refluxed until the hydrogen evolution had subsided. The reac-' tion mixture was cooled and directly treated with 16.0 g. methyliodide at a temperature between 25-40C. Sodium iodide separated while the reaction mixture was stirred overnight at room temperature. Ether was added, the inorganic salt separated by filtration, and the filtrate evaporated to dryness. The oily residue was distilled to yield 3,4-dihydro-l,3-dimethyl-l-allyl 3 carbomethoxy-7-met'hoxy-naphthalen-2( 1fl)-on"e boiling at l50C./0.015 mm. and identical with the product obtained by Procedure A of this Example.

Following the above procedure but substituting ethyliodide in molar equivalent amount during the alkylation step for methyliodide there is obtained 3,4- dihydro- 1 -methyl-3-ethyl- 1 -a1lyl-3-carbomethoxy-7- methoxy-naphtha1en-2( lfl)-one. B.P.=1 13- ll4C./0.001 mm. Hg; M 5.75p.(-QQOCH;,), 5.88;]. C=O); NMR (CDC1 81.15(t, 3H), 63.68 (s, 3H), 53.80 (s, 3H), 85.0 (m, 3H).

3 ,4-Dihydro- 1 -methyl-3-propyll -allyl-3- carbomethoxy-7-methoxynaphthalene-2 1H)-one was prepared in similar fashion and distilled at 142C./0.01 mm Hg; h f 5.70,u.(ester), 5.80 1. (ketone), 6.05;; (-CH=CH NMR (CDC1 exhibited chemical shifts at 3.68 (s,COOC1-l 53.81 (s,OCH 55.03 (m, -C l -l;=C1-1 Mass spectrum showed the following major fragmentations m/e 330 (M 314, 289, 287, 273, 257, 229 (base), 201, 173.

Analysis for C d-1 Calc.; C, 72.70; H, 7.93%. Found; C, 72.99.; H, 8.07%

Following the above procedure, but substituting 3,4- dihydro-1-ethyl-1-allyl-3-carbomethoxy-7-methoxynaphtha1en-2( 1 1 1 )-one for 3,4-dihydro-1-methyl-1- a11yl-3-carbomethoxy-7-methoxy-naphthalen- 2(1 1- 1 )one, there is produced 3,4-dihydro-3-methyl-1- ethyll -allyl-3-carbomethoxy-7-methoxy-naphthalen- 2( l 1 1 )-one and 3,4-dihydro-1 ,3-diethyl 1 -allyl-3- carbomethoxy-7-methoxy-naphthalen2( lfl)one( V;.

EXAMPLE 5 3,4-Dihydro-l ,3'dimethyl-1-al1y1-7-methoxynaphthalen-2( 1 1;1 )-one A solution of 59.0 g. of 3,4'dihydro-1,3-dimethyl-3- carbomethoxy-7-methoxy-naphthalen-2(11 )-one in 450 ml. of 5% KOH/methanol was refluxed for 1-5 hours. K CO deposited during the reaction and was removed by filtration. The methanolic filtrate was evaporated to dryness. The resulting oily residue was dissolved in ether, and the ether solution washed with water, and dried. The dried ethereal solution was distilled in vacuo, and the fraction boiling in the range 131133C./0.06 mm Hg. collected, the yield was 45.1

g. of 3,4-dihydro-1,3-dimethyl-1-allyl-7-methoxynaphthalen-2(1 1i)-one; b.p. 121124C./0.001 mm Hg. (glc purity 91.5%); u 3.23p.(-CH=CH 5.85 J.( C=O),

6.02p.(CH=CH2); NMR (CDC1 exhibited chemical shifts at 51.05 (d, 3H; J 7 cps), 81.43 (s, 3 H), 83.78 (s, 3H), 55.10 (m, 3H).

Mass spectrum showed the following major fragment ions: m/e 244 (NH), 229, 203, 175 (base).

Analysis for C A-1 0 244.32 requires: C, 78.63; H, 8.23%. found: C, 78.41; H, 8.08%

Following the above procedure, but substituting for 3,4-dihydro-l ,3dimethyl-1-allyl-3-carbomethoxy-7- methoxy-naphthalen-2-( lw-one an appropriately substituted 3 ,4-dihydro-1,3-dialkyl-1-a1lyl-3- carbomethoxy-7-methoxy-naphthalen-2( lw-one, there is produced 3,4-dihydro-1-methy1-3-ethyl-l-ally1- 7-methoxy-naphthalen-2-( l l;l )-one b.p. 118C./0.001 mm. Hg; )\,,,,,j' 5.87,u( C=O); NMR (CDCI 60.98 (t, 3H), 61.02 (t, 3H), 51.35 (s, 3H), 51.43 (s, 31-1),63.80 (s,3H),55.20(m, 3H).

Mass spectrum exhibited the following major frag mentions m/e 258 (M*), 217, 189 (base).

Analysis for 11 0 258.35 requires: C, 79.03; H, 8.58%. found: C, 78.78; H, 8.56%

3,4Dihydro-1-methyl-3-propyl-1-ally1-7-methoxynaphthalene2-(1H)-one was obtained in similar fashion; b.p. 140C./0.1 mm Hg; k 582p. (ketone), 6.05;.1. (-CH=CH NMR (CDCl possessed chemical shifts at 53.75 (s, OCH 85.15 (m, -Cfl=CH Mass spectrum exhibited the following major fragTtent-ions m/e 272 (M*), 245, 231, 203 (base), 187, 175, 173, 161.

3,4-Dihydro-3-methyl-l-ethyl-1a1lyl-7-methoxynaphthalen-2(1 1;1 )-one, 3,4-dihydro-1,3-diethyl-1-allyl- 7-methoxynaphthalen-2(1l )-one and 3,4-dihydro-3 methyl-1 n-propyl-1-a1lyl-7-methoxynaphthalen- 2( lfl)-one are prepared in similar fashion.

EXAMPLE 6 1,2,3 ,4-Tetrahydro- 1 ,3dimethyl-7-methoxy-2-oxo- 1 naphthalene-acetaldehyde A solution of 28.8 g. of 3,4-dihydro-1,3-dimethyl-1- allyl-7-methoxy-naphthalen-2( 1 l- 1 )-one in 300 ml. of dichloromethane was ozonized between 20 and -C. After the o'zonization of the allylic side chain was complete, 75 ml. of acetic acid were added to the reaction mixture. The ozonide was then reductively cleaved by the addition of 22 g. Zinc dust which was added in small batches to the vigorously stirred reac tion mixture. The temperature was maintained in the range 2030C. After the ozonide was cleaved, the reaction mixture was filtered, and the organic layer was twice extracted with water and once with sodium bicarbonate solution thereby removing the last trace of acetic acid. The organic layer was dried, filtered and evaporated to dryness. The residue, comprising 1,2,3,- 4-tetrahydro- 1 ,3dimethyl-7-methoxy-2-oxo- 1 -naphthalene-acetaldehyde, was distilled at l50155C./0.01 mm. Hg; yield (several runs) 86-94%; x f' 363p. (CL1 O), 5.83,u. (aldehyde oxo), 5.88 1. (ketone). Mass spectrum exhibited the expected molecular ion m/e at 246 fragment peaks occurred at m/e 204, 203, 202, 175 and 161.

Following the above procedure, but substituting for 3,4-dihydro-1 ,3-dimethyl-1-al1yl-7methoxynaphthalen-2( lw-one an appropriate 3,4-dihydro-1 ,3- dialkyl-1-al1yl-7-methoxynaphthalene-2( lib-one, there is produced l,2,3,4-tetrahydro-1-methy1-3-ethyl- 7-methoxy-2-oxo-1-naphthalene-acetaldehyde b.p. C./0.00l mmg. Hg.; h 3.65 (C 1iO), 5.80u (CHQ), 5.85 1. (C=O); NMR (CDC1 81.0 (t, 3H), 51.50 (s, 3H), 63.80 (s, 3H), 612,1 (m, 1H). Mass spectrum exhibited a molecular ion m/e at 260 (M*) and the following major fragment ions: m/e 246. 218, 217, 216,189, 176, 175,162 and 161 (base).

1 ,2,3,4-tetrahydro-1-ethyl-3-n-propyl-7-methoxy-2- oxo- 1 -naphthalene-acetaldehyde; l,2,3,4-tetrahydro- 3-methyl-1-ethy1-7-methoxy-2-oxo-l-naphthaleneacetaldehyde and 1,2,3,4-tetrahydro-1.3-diethyl-7- methoxy-2-oxo-1-naphthalene-acetaldehyde can be prepared in similar fashion.

EXAMPLE 7 6,7,8,9-Tetrahydro-5,8-dimethyl 3methoxy-5 ,8- methano-Sfi-benzocycloheptene-7-ol- 1 O-one A solution of 28.6 g. of l,2,3,4-tetrahydro-l,3- dimethyl-7-methoxy-2-oxo-l-naphthaleneacetaldehyde in 400 m1. of methanol was treated with 200 ml. of 2% KOH-methanol. The reaction mixture was left at room temperature for 16 hours. The solvent was evaporated in vacuo, and the resulting residue was dissolved in ether. The ether extract was in turn extracted with 10% hydrochloric acid at 0C. and then with water. The ether solution was dried and evaporated to yield a residue comprising 6,7,8,9-tetrahydro- 5,8-dimethyl-3-methoxy-5,8-methano-5l-l; benzocycloheptene-7-ol-lO-one; weight 27.6 g.; 2.88;;(strong OH), 5.75p.(five-membered ketone).

Following the above procedure, but substituting for l,2,3,4-tetrahydrol ,3.dimethyl-7-methoxy-2-oxol naphthalene-acetaldehyde the appropriate 1,2,13,4- tetrahydro-l ,3-dialkyl-7-methoxy-2-oxo-1-naphthalene-acetaldehyde, one obtains 6,7,8,9-tetrahydro-5- methyl-8-ethyl 3-methoxy-5,8-methano-5flbenZocycloheptene-7-ol-l0-one; yield 96.5%; h 2.80/.L(-OH), 5.75,u(five-membered ketone).

Similarly, 6,7,8,9-tetrahydro-5-ethyl-8-n-propyl-3- methoxy5,8-methano- 5fl -benzocycloheptene-7ol-lO-one; 6,7, 8,9- tetrahydro-8-methyl-5-ethyl-3-methoxy-5,S-methano- 5 li-benzocycloheptene-7ol-IO-one, 6,7,8,9- tetrahydro-S,8-diethyl-3-methoxy-5,8-methano-5flbenzocycloheptene-7-oll O-one and 6,7,8 ,9-. tetrahydro-S-methyl-8-n-propyl-3-methoxy-5,8- methano-5fl-benzocycloheptene-7-ol-lO-one can 'be synthesized from the appropriate starting material.

EXAMPLE 8 6,7,8 ,9-Tetrahydro-5 ,8-dimethyl-3-methoxy-7- (tetrahydro-Z-pyranyloxy )-5,8-methano-5fl-benzocycloheptenl O-one 27.6 g. of 6,7,8,9-tetrahydro-5,8-dimethyl-3- methoxy-S,S-methano-Slibenzocycloheptene-7-ol- I lO-one were dissolved in about 50 ml. of dihydropyran. A few crystals of p-toluene-sulfonic acid were added. The resulting exothermic reaction was controlled by a cooling bath, and the internal temperature was kept below 35C. After the exothermic reaction had subsided, the mixture was allowed to stand for anothe'r' 4 hours at room temperature, and was then diluted with ether. The ether layer was separated and extracted by sodium bicarbonate solution, dried, filtered and evaporated to dryness, yielding as a residue the crude tetrahydropyranyl ether of 6,7,8,9-tetrahydro-5,8-dimethyl- 3-methoxy-7-( tetrahydro-Z-pyranyloxy )-5 ,S-methano- EXAMPLE 9 6,7,8 ,9-Tetrahydro5 ,8-dimethyl-3-methoxy-7- (tetrahydro-Z-pyranyloxy 1 O-methylene-S .8- methano-Sli-benzocycloheptene pyranyloxy-S ,8-methano-' additional hour and then treated with a solution of 50.3

g. of 6,7,8,9-tetrahydro-5,8-dimethyl*3-methoxy-7- (tetrahydro-Z-pyranyloxy)-5,8-methano-5H-benzocycloheptene-lO-one in 100 ml. of dimethylsulfoxide. The addition took about 10 minutes, and the moderately exothermic reaction was kept at a temperature in the range 243 5C. The dark brown mixture was stirred for an additional hour between 4050C. and stored at room temperature overnight. The mixture was then poured onto an ice-water mixture and thoroughly extracted with hexane. Triphenylphosphoniumoxide formed as a by-produce in the reaction was insoluble in both water and aliphatic hydrocarbons and was separated by filtration. The dried organic filtrate was evaporated to dryness in vacuo leaving a residual yellow gum comprising 6,7,8,9-tetrahydro-5,8-dimethyl-3-methoxy -tetrahydro-5-methyl-8-propyl-3-methoxy-7- (tetrahydro2-pyranyloxy)-lO-methylene-5,8- methano-SH-methano-SH-benzocycloheptene; 6.7,8,9- tetrahydro-8-methyl-5-ethyl-3-methoxy-7-(tetrahydro- 2-pyranyloxy)-10-methylene-5 ,8-methano-5fi; benzocycloheptene and 6,7,8,9-tetrahydro-5,8-diethyl- 3-methoxy-7(tetrahydro-2-pyranyloxy l O- methylene-5,8-methano-5fl-benzocycloheptene.

EXAMPLE l0 6,7,8,9-Tetrahydro-5 ,8-dimethyl-3-methoxyl 0- methylene-5,8-methano 5l -l -benzocycloheptene-7ol A solution of 28.1 g. of 6,7,8,9tetrahydro-5,8- dimethyl-3-methoxy-7-(tetrahydro-Z-pyranyloxy)-10- methylene-S,8-methano-5 li-benzocycloheptene in 300 ml. of 5% ethanolic oxalic acid containing 10 ml. of water was refluxed for 5 hours. The evaporated reaction mixture was dissolved in benzene, and the benzene solution extracted with dilute aqueous sodium hydroxide and water. The benzene solution was separated and dried. Evaporation in vacuo yielded residue of 21.0 g. of an orange-colored gum comprising 6,7,8,9- tetrahydro-S,8-dimethyl-3-methoxy-l0-methylene-5,8- methano-5 ll -benzocycloheptene-7ol; 2.95,u.(OH), 3.27p. and 6.03p.( C=CH Following the above procedure, but substituting for 6,7,8,9-tetrahydro-5,8-dimethyl-3-methoxy-7- (tetrahydro-Z-pyranyloxy)-l-methylene-5,8- methano-l1 -benzocycloheptene an appropriate 6,7,8,- 9-tetrahydro-5,8-dialkyl-3-methoxy-7-(tetrahydro-2- pyranyloxy l O-methyIene-S,S-methano-SH; benzocycloheptene, one can obtain. 6,7,8,9-tetrahydro- 5*methyl-8-ethyl-3-methoxyl O-methylene-5.,8' methano-5 1;l -benzocycloheptene-7-ol b.p.=131C./0.004 mm. Hg; A f .a 2.80, 2.90;.( OH), 6.O5;1.( C=CH2);NMR, (CDCI 81.03 (t, 3H), 81.48 (s, 3H), 83.77 (s, 3H), 84.77 and 4.80 (two singlets for C=Cl1 7 Mass spectrum shows the M -ion m/e at 258 and fragment ions at m/e 243, 226, 225, 214, 211, 199 and 185 (base).

Analysis for C I-1 0 258.35 requires: C, 79.03; H, 8.50%. found: C, 78.93; H, 8.86%.

6,7,8,9-Tetrahydro-5-ethyl-8-n-propyl-3-methoxy- -methylene-5,S-methano-Sli-benzocycloheptene-7- o1,

. EXAMPLE 1'1 6,7,8 ,9-Tetrahydro-5 ,8-dirneth yl-3-methoxy- 10- v methylene-5,8-methano-5fl-benzocycloheptene- A solution of 28.3 g. of 6,7,8,9-tetrahydro-5,8- dimethyl-3-methoxy- 1 O-methylene-S ,8-rnethano-5-H- benzocycloheptene-7-ol in 50 m1.. pyridine was slowly introduced into a slurry of 23.0 g. of CrQ in 300 ml. pyridine. The reaction mixture was stirred at room temperature for about 16 hours and was then diluted with ether. Inorganic material was separated byfiltration. The filtrate was evaporated to a dark syrup which was extracted with ether. The ethereal extract was washed with dilute hydrochloric acid and water and was then dried. Evaporation of the solvent in vacuo yielded crude 6,7,8,9-tetrahydro-5,8-dimethyl-3-methoxy-10- methylene-5,8-methano-5 li-benzocycloheptene-7-one in quantitative yield, which crystallized upon standing. After recrystallization from ethanol-hexane, the compound melted at 84-85.5C. 5.75p.( C=O), 6.0,LL( C=CH2); NMR (CDCl;,) 81.29 (s, 3H), 81.79 (s, 3H), 82.44 (s, 1H), 8 2.49 (s, 1H), 82.90 (s, 1H), 82.95 (s, 1H), 83.77 (s, 3H), 84.91 (s, 1H), 85.0] (s, 1H)- Mass spectrum exhibited the following major fragment ions: m/e 242 (M'), 227, 200, 199 and 185 (base).

Analysis for C H O 242.30 requires: C, 79.31; H, 7.49%. found: C, 79.10; H, 7.55%

yield of 80.7% of the desired product.

Following the above procedure but substituting for 6,7,8,9-tetrahydro-5,8-dimethyl-3-methoxy-l0- methylene-5,8-methano-5H-benzocycloheptene-7-ol an appropriate 6,7,8,9-tetrahydro-5,8-dialkyl-3- methoxy- 1 O-methylene-S ,8-methano-5 li-benzocycloheptene-7-ol, one can obtain 6,7,8,9-tetrahydro-5- methyl-8-ethyl-3-methoxy-l0-methylene-5,8-methano- Sfl-benzocycloheptene-7-one; m.p.=1031 04C.; k 3 5.75p.(five-membered ketone), 6.03I,L( C=CH2); NMR (CDC1 8.86 (t, 3H), 81.70 (s, 3H), 83.75 (s, 3H), 84.90 (s, 1H), 85.10 (s, 1H).

Mass spectrum showed the following major fragment ions: m/e 256 (M'), 241, 203, 199, and 185 (base).

Analysis for C H O 256.33 requires: C, 79.65; H. 7.86%. found: C, 79.53;'H, 7.64%.

6,7,8,9-Tetrahydro-5-methyl-8-propyl-3-methoxylO-methylene-5 ,8-methano-Sfl-benzocycloheptene- 7-one was obtained in similar fashion and recrystallized from ethanol; m.p.= ll8.5l19.5C.; ,u.,,,,,,."' 5.73,u.(five-membered ring ketone), 6.0 C=CH NMR- (CDCl exhibited the following chemical shifts 80.99 (t,3H,(CH -CH 81.69 (s, 3H, C-C1j 83.77

84.91 and 5.09 (singlets, 2H for C=CH Mass spectrum showed the following major fragnTe nt-ions m/e 270 M), 255 (base), 241, 227, 213, 199, 185, 171.

Other compounds preparable by the above procedure include 6,7,8,9-tetrahydro-8-ethyl-3-methoxy-l0- methylene-5,8methano-5E;benzocycloheptene-7-one and 6,7,8 ,9-tetrahydro-5,8-diethyl-3-methoxy-10- methylene-5,8-methano-5fl-benzocycloheptene-7-one.

EXAMPLE 12 6,7,8,9-Tetrahydro-5 ,8, l0-trimethyl-3-methoxy-5 ,8-

methano-Sfl-benzocycloheptene-7-one PROCEDURE A A solution of 22.4 g. of 6,7 ,8,9-tetrahydro-5.8- dimethyl-3-methoxy-10-methylene-S,S-methano-Slibenzocycloheptene-7-one in 350 ml. of ethanol was catalytically reduced over 5 g. of prehydrogenated Pd/C catalyst at atmospheric pressure. (Other catalysts e.g. Pt, Ni, were also useful to hydrogenate the ex omethylene group). Afterthe hydrogenation had been completed, the catalyst was separated by filtration, and the reaction mixture was evaporated to a colorless syrup. 1

The crude reaction mixture was purified .by distillation at -125C.10.01 mm. Hg.; 1 5.73u(ketone), and a 3:2 mixture of the cisand trans- C /C -Me stereoisomers of 6,7,8,9-tetrahydro-5,8,10- trimethyl-3-methoxy-5,8-methano-5fl-benzocyclohep tene-7-one was obtained in high yield. NMR spectrum of the C C -Me cis isomer exhibited chemical shifts at 80.84 ((1, 3H; J=7 cps),'8l.07 (s, 3H), 81.47 (s. 3H), 83.77 (s, 3H). The NMR spectrum of C5/C|0-Me trans isomer possessed chemical shifts at 81.00 (d, 3H; .1=7 cps), 81.12 (s, 3H), 81.5l (s, 3H), 83.77 (s, 3H).

Analysis for C H O 244.32 requires: C, 78.65; H, 8.25%. found: C, 78.93; H, 8.60%

Following the above procedure, but substituting for 6,7,8,9-tetrahydro-5,8-dimethyl-3-methoxy-1 0- methylene-5,8-methano-Sfl-benzocycloheptene-7-one the appropriate 6,7,8,9-tetrahydro-5,8-dialkyl-3- methoxy-lO-methylene-S,8-methano-H-benzocycloheptene-7-one, one can obtain 6.7,8-,9-tet-ra hydro- 5,10-dimethyl-8-ethyl-3-methoxy-5,8-methano-5fl- I benzocycloheptene-7-one; b.p.=l C./0.005 mm. Hg.; )t f 5.80 (ketone). NMR spectrum of the C IC -Me cis isomer (CDC|,,) exhibited chemical shifts at 50.83 (t, 3H), 80.8] (d, 3H; J=7cps), 81.52 (s, 3H), 53.76 (s, 3H). The NMR spectrum of the C,-,/C Me trans isomer (CDCI possessed chemical shifts at 51.00 ((1, 3H; J=7 cps), 51.52 (s, 3H), 83.76 (s, 3H).

Reduction of 6,7,8,9-tetrahydro-5-methyl-8-ethyl-3- methoxy-lO-methylene-S,S-methano-SH-benzocy-j cloheptene-7-one with Pd-C 10%) catalyst led to a 2:3 mixture of cisand trans- C -,/C Me-stereoisomers. Reduction with PtO catalyst provided a 4:1 mixture of the cisand trans-diastereoisomers.

Mass spectrum showed the following major fragment ions: m/e 258 (M*, base), 243, 229, 215, 201, l'87and 175. Y Analysis for C H- O 258.35 requires: C, 79.03; H', 8.58%. found: C, 79.03; H, 8.84%.

6,7,8,9-Tetrahydro-5,l0-dimethyl-8-propyl-3- methoxy-S,8methano-SH-benzocycloheptene-7-one was prepared in similar fashion and was isolated after recrystallization from hexene; m.p. 5l55C. Glc analysis on Se-30 column showed that the ratio of the axial and equatorial diastereoisomer is 9] :9. )t,,,,,,""' 5.75p. (five-membered ring ketone); NMR spectrum (CDCL'!) showed no chemical shift for the vinyl protons. A triplet for the CH group of the propyl sidechain and the two sets of doublets for the axial and' equatorial C -CH protons were not completely re solved. However, the C,=,CH protons of the two d ia-' stereoisomers exhibited two singlets" corresponding to the methyl protons at 61.53 (s, C-CH3); and 61 .48 (s,

C-CH3). respectively. Mass spectrum possessed the following major fragment-ions m/e 272 (M-*), 257,- 243, 229, 215, 201, 199, 187, 175 (base).

8.88%. found: C, 79.60, H, 8.91%

Other compounds preparable by following the above procedure include 6,7,8,9-tetrahydrolO-methyI-S- ethyl-8-n-propyl-3methoxy-5,8-methano-5H-benzocy cloheptene-7-one, 6,7,8,9-tetrahydro-8,lO-dimethyl-5- v ethyl-3-methoxy-5 ,8methano-5H;benzocycloheptene 7-one and 6,7,8,9-tetrahydro-l0-methyl-5,8-diethyl-3- methoxy-S,8-methano-SH-benzocycloheptene-7-o ne'.

EXAMPLE l3 6,7,8,9-Tetrahydro-5,8-dimethyl-3-methoxy-7- 1 (tetrahydro-Z-pyranyloxy)-l0-hydroxymethyl-5,8-

methano-Sfl-benzocycloheptene x A solution of 26 ml. of 1 molar diborane in tetrahy drofuran was slowly dropped into a solution of 17.3 g. of (tetrahydro-Z-pyranyloxy lO-methylene-5,8-

methano-Sfl-benzocycloheptene dissolved in 50 of I dry tetrahydrofuran held betwen.0 and C. After the addition had been completed, the reaction mixture was stirred at room temperature for about 1 hour and then" Evaporation of the combined chloroform extracts to;

6,7,8,9-tetrahydro-5,S-dimethyl3-methoxy-7- Analysis for c a o 272.37 requires: c, 79.37, Hu

16 dryness gave crude 6,7,8,9-tetrahydro-5,8 dimethyl-3- methoxy-7'-(tetrahydro 2pyranyloxy)-l0- hydroxymethyl-S,8-methano-5fl -benzocycloheptene in practically quantitative yield; A,,,,, 2.95,u.(very strong-OH); there was no absorption band at'6.07p. for the exomethylene group.

Following the above procedure, but substituting for 6,7,8,9-tetrahydro-5,8-dimethyl-3-methoxy-7- (tetrahydrO-Z-pyranyloxy)-l0 methylene-5,8- methano-Sfl-benzocycloheptene an appropriate 6,7,8,- 9-tetrah'ydro-5,8-dialkyl-3-methoxy-l7-(tetrahydro-Z- pyranyloxy)-l0-methylene 5,8-methano-5 l;l benzocycloheptene, one can obtain 6,7,8,9-tetrahydro- 5-methyl-8-n-propyl-7-(ttfahydro-Z-pyranyloxy)-10- hydroxymethyl-5,8-methano-5fl-benzocycloh,eptene, 6,7,8,9-tetrahydro-5methyl8-ethyl-3-methoxy-7- (tetrahydro-2 pyranyloxy)- l 0-hydroxymethyl-5,8- methanO'SH-benzocycloheptene, 6,7,8,9-tetrahydro-8 methyl-5-ethyl 3-methoxy-7-(tetrahydro-2- pyr'anyloxy)-lO-hydroxymethyl-S,8-methano-3l-l; benzocycloheptene and 6,7,8,9-tetrahydro-5,8-diethyl- 3-methoxy-7-( tetrahydro-2-pyranyloxy)- 10- hydroxymethyl-S,8-methano:SH-benzocycloheptene.

EXAMPLE l4 6,7,8,9-Tetrahydro-5 ,8-dimethyl-3-methoxy-7- tetrahydro-Z-pyranyloxy l 0-tosyloxymethyl-5,8- methano-5kl -benzocycloheptene methano-Sfi-benzocycloheptene; A 3.47;.L(very 1 strong CH), 7.37 and 8.50;1.(SO and there was no band for OH absorption. I

Following the above procedure,.but substituting for 6,7,8,9-tetrahydro-5,8-dimethyl-3-methoxy-7- (tetrahydr'o-Z-pyranyloxy l 0-hydroxymethyl-5 ,8-

methano-5 l;l benzocycloheptene an appropriate 6,7,8}

9 tetrahydro- .5,8-dialkyl3-methoxy-7-(tetrahydro-2 pyranyloxy)'- lO-hy droxymethyI-S,8-methano-5 l-L benzocycloheptene, one can obtain 6,7,8,9-te trahydro 5-methyl-8-ethyl 3-methoxy-7-(tetrahydro-2-- pyranyloxy)-l0-tosylox ymethyl-5,8-methano 5H benzocycloheptene; 6,7,8,9-tetrahydro-5-m ethyl 8- propyl-3-methoxy-7-(tetrahydro-Z-pyranylbxy l 0- tosyloxymethyl-5,8-methano-Sfl-benzocycloheptene and (tetrahydro-2-pyranyloxy l O-tosyloxymethyl-S ,8- methano-Sfl-benzocycloheptene.

EXAMPLE 15 6,7,8,9 Tetrahydro-5,8.lO-trimethyl-3-methoxy-5,8-

methano-5&benzocycloheptene-7-ol A solution of 24.4 g. of 6,7,8,9-tetrahydro-5,8-

dimethyl-3-methoxy-7( tetrahydro-2-pyranyloxy l 0- tosyloxymethyl-S ,8-methano-5 H -benzocycloheptene in 200 ml. of dry tetrahydrofuran was slowly introduced into a slurryof 5 g. of LiAlH, in ml. of dry tetrahydrofuran. The resultingmixture was refluxed for 16 6,7,8,9-tetrahydro-5,8-diethyl-3-methoxy 7- hours. The reaction mixture was decomposed with an ice-water mixture followed by 10% hydrochloric acid which treatment also served to hydrolyze the tetrahydropyranyl-ether group. The reaction mixture was extracted with ether. Evaporation of the ether solvent gave a practically quantitative yield of crude 5,8,10- trirnetlryl-S,8-rnethano-Sfl-benzocycloheptene-7-ol; 2.98,u(very strong OH).

Following the above procedure, but substituting for 6,7,8,9-tetrahydro-5,8-dimethyl-3methoxy-7- (tetrahydro-Z-pyranyloxy)-10-tosyloxymethyl-5,8- methano-5;H -benzocycloheptene an appropriate 6,7,8,- 9tetrahydro-5,8-dialkyl-3-methoxy-7-(tetrahydro-2- pyranyloxy l O-tosyloxymethyl-S,8-methano5 H benzocycloheptene. one can obtain 6,7,8,9-tetrahydro- 5,10-dimethyl-3-methoxy-8-n-propyl-5 ,8-methano-5 H benzocycloheptene-7-ol, 6,7,8,9-tetrahydro5, 10- dimethyl-8-ethyl-3-methoxy-5,8-methano-5H- benzocycloheptene-7-ol, 6,7,8,9-tetrahydro-8, l dimethyl--ethyl-3-methoxy-5,8-methano-5fl; benzocycloheptene-7-ol and 6,7,8,9-tetrahydro-10- methyl-5,8-diethyl-3 methoxy-5,8-methano-5 l;l benzocycloheptene-7-ol EXAMPLE 16 6,7,8,9-Tetrahydro-5,8,10-trimethyl-3-methoxy-5,8- methano-Sli-benzocycloheptene-7-one PROCEDURE B A solution of 16.0 g. of 6,7,8,9'tetrahydro-5,8,10- trimethyl-3-methoxy-5,8-methano-SH-benzocycloheptene-7-ol in 100 ml. of pyridine was slowly added to a slurry of 13.0 g. of CrO in 150 ml. of pyridine. The reaction mixture was kept at room temperature with stirring for an additional 16 hours. The reaction mixture was filtered, the filtrate was evaporated to a dark syrup which was dissolved in ether, and the ether solution extracted with 10% hydrochloric acid. Evaporation of the ethereal solution yielded crude 6,7,8,9-tetrahydro- 5,8 l 0-trimethyl-3-methoxy-5 ,8-methano-5 ll-benzocycloheptene-7-one in practically quantitative yield. Distillation of an aliquot of the syrup at l30135C./0.0l mm. Hg. gave the pure C /C -trans-stereoisomer of 6,- 7,3,9-tetrahydro5,8,l0-trimethyl-3-methoxy-5,8- methano-Sfi-benzocycloheptene-7-one. NMR spectrum was identical with the sample obtained by a different route in Example 12 and exhibited chemical shifts for the C /C, ,-trans-dimethyl groups at 81.03 ppm. ((1,

=7 cps; C ,C H 81.12 (s, C C H 81.51 ppm. (singlet, for C CH and 83.77 (s; O C lj Following the above procedure, but substituting for 6,7,8,9-tetrahydro-5,8,10-trimethyl-3-methoxy-5,8- methano-5;H -benzocycloheptene-7-ol, an appropriate 6,7 ,8 ,9-tetrahydro-5,8, 1 0-trialkyl-3-methoxy-5,8- methano-5H -benzocycloheptene-7-o1, one can obtain 6,7 ,8 ,9-tetrahydro-5, 1 O-dimethyl-8-ethyl-3methoxy- 5,8-methano-5H-ben2ocycloheptene-7-one, m.p.=74-75 (from pentane), 6,7,8,9-tetrahydro 5,10-dimethyl-8-n-propyl-3-methoxy-5,8-methano-5H; benzocycloheptene-7-one; m.p. 118.5l19.5C. (ethanol) 6,7,8,9-tetrahydro-8,10-dimethyl-5-ethyl-3- methoxy-S,8-methano-5fl-benzocycloheptene-7-one and 6,7,8,9-tetrahydro-10-methyl-5,8-diethyl-3- methoxy-S,8-methano-5 H -benzocycloheptene-7-one.

EXAMPLE 17 6,78 ,9-Tetrahydro-5 ,8,10-trimethyl-3-methoxy-5,8- methano-Sfibenzocycloheptene-7-one oxime A solution of 22.7 g. of 6,7,8,9-tetrahydro-5,8,l0- trimethyl-3-methoxy-5,8-methano-5-H-benzocycloheptene-7-one in 60 ml. of methanol containing a 1.5 mol equivalent amountof hydroxylamine acetate was refluxed for about 5 hours. The reaction mixture was evaporated to dryness, and the residue extracted with ether. The dried ethereal layer gave 23.0 g. of a gum on evaporation to dryness. Recrystallization of the gum from ether-hexane yielded the pure oxime which melted at 144.5145.5C.; A,,,,, ""=3.O5p.(OH). NMR spectrum exhibited chemical shifts for its C1nCH protons at 80.75 ((1, J =7cps), which indicates a Cs/Cw-cis-dimethyl configuration. Mass spectrum exhibited the following major fragment ions: m/e 259 (M*), 244, 242 (base), 201.

Analysis for C H NO 259.33.

requires: C, 74.10; H, 8.16; N, 5.40%.

found: C, 73.94; H, 7.96; N, 5.23%.

A similar procedure starting from the transC /C dimethyl diastereoisomer from Example 16, yielded the isomeric oxime, m.p.=190l93C. NMR spectrum verified the trans-stereochemistry of the C,-,/C -methyl groups possessing chemical shifts for its C -methyl protons at 80.94 (cl, 3H: J=7 cps).

Following the above procedure but substituting for 6,7,8,9-tetrahydro-5,8,10-trimethyl-3-methoxy-5,8- methano-5 li-benzocyc1oheptene-7-one an appropriate 6,7,8,9-tetrahydro-5 ,8, l O-trialkyl-3-methoxy-5,8- methano-5fl-benzocycloheptene-7-one, one can obtain 6,7,8,9-tetrahydro-5,10-dimethyl-8-ethyl-3-methoxy- 5,8-methano-Sfl;benzocyc1oheptene-7-one oxime. The trans-C /C -Me isomer melted at l95.5-l96.5C.; 3.0,u(broad-OH); MHz NMR spectrum in CDC1 showed chemical shifts at 80.96 (t, 3H), 81.41 (s, 3H), 81.69 (q, 2H), 82.04 (q, 1H), 83.77 (s, 3H). The cis-C /C, ,-Me isomer melted at l26.5132.5C. NMR spectrum indicated a mixture of 87% cisand 13% transisomers. NMR spectrum of the ure cis-isomer exhibited chemical shifts at 80.74 (t, 3H), 81.45 (s, 3H) and 83.75 (s, 3 H).

Mass spectrum of the oxime showed the following fragment peaks: m/e 273 (M*), 258, 256, 215 (base), 187, 186.

Analysis for C,,H NO 273.36. requires: C, 74.69; H, 8.48; N, 5.12%. found: C, 74.76; H, 8.64; N. 5.30%.

6,7,8,9-Tetrahydro-5,10-dimethyl-8-n-propyl-3- methoxy-S,8-methano-5H-benzocycloheptene-7-one oxime was prepared in similar fashion; m.p. 158161C. (from benzene-heptane); k f 2.80, 3.0011. (-OH). Mass spectrum possessed the following major fragment-ions m/e 287 (M*), 272, 229 (base). 200, 187, 172.

Analysis for C H NO, 287.39. requires: C, 75.22; H, 8.77; N, 4.87%. found: C, 75.41; H, 8.57; N, 4.86%.

6,7,8,9-Tetrahydro-8, 1 O-dimethy15-ethyl-3- methoxy-5,S-methano-Sttbenzocycloheptene-7-one oxime and 6,7,8,9-tetrahydro-l0-methyl-5,8-diethyl-3- methoxy-S,8-methano-5 li-benzocycloheptene-7-oneoxime can be obtained in similar fashion.

EXAMPLE 18 1,2,3,4,5,6-Hexahydro-2,6-l l-trimethyl-S-methoxy- 2,6-methano-3-benzazocine-4-one An ice-cold solution of 25.9 g. of the cis-C lC dimethyl diastereoisomer of 6,7,8,9-tetrahydro-5,8,10- trimethyl-3-methoxy-5,8-methano-SH-benzocycloheptene-7-one oxime in 500 ml. of pyridine was treated with 19.0 g. p-tosylchloride and the resulting mixture stirred at C. for 16 hours. The mixture was allowed to warm up to room temperature at which temperature it was maintained for 24 hours. The reaction mixture was evaporated in vacuo at 30C. bath temperature to a syrup which was dissolved in benzene. The benzene solution was extracted with hydrochloric acid and water and dried. Evaporation of the benzene yielded about 35-40% of the cis-C C -Me isomer lactam. Re'- crystallization from ethylacetate hexane yielded purified cis lactam; m.p. =2()0201.5C.; A 3.20; (sharp NH); 6.03pt(strong-Q-NH). 100 MHz NMR spectrum in DMSO-d exhibited the diamagnetically shifted C -methyl protons at 80.79 (d, 3H).

Mass spectrum showed the following fragmentation: m/e 259 (M'), 244, 200, 161, 138.

Analysis for C H NO 259.33. requires: C, 74.10; H, 8.16; N, 5.40%. found: C, 73.87; H, 8.37; N, 5.38%.

Similar Beckmann rearrangement of the C /C trans-dimethyl oxime diastereoisomer yielded the c /C -transdimethyl diastereoisomer of l,2,3,4,5,6- hexahydro-2,6,1 1-trimethyl-8-methoxy-2,6-methano- 3-benzazocine-4-one m.p.=209.5-210C. NMR spectrum verified the trans-diequatorially oriented C /C methyl groups by exhibiting the C -methyl protons at 80.96 (d, 3H) in DMSO-d so1ution.

Following the above procedure, but substituting for 6.7.8.9-tetrahydro-5 ,8, l 0-trimethyl-3-methoxy-5 ,8- methano-5 li-benzocycloheptene 7-one oxime an appropriate 6,7,8.9-tetrahydro-5 ,8,10- trialkyl- 3'- methoxy-S,8methano-5H-benzocycloheptene-7-one oxime, one can obtain l,2,3,4,5,6-hexahydro 6,l 1- dimethyl-2-ethyl-8-methoxy-2,6-methano3- I benzazocine-4-one. The cis-C lC -methyl diastereoisomer lactam was recrystallized from CHCl -ether; m.p.=l 64 1 67C. A,,,,,,'" 3'.20p.( NH 6.05,u(Q)NH).

Mass spectrum possessed a weak molecularion: 273 (M*) and the following major fragment ions: m/e 258 (base), 215, 214,187 and 175.

Analysis for C, H NO- 273.36. requires: C, 74.69; H, 8.48; N, 5.12%. found: C, 74.46; H, 8.21; N, 5.03%. The trans-c lC -methyl stereoisomer lactarri melted at 285286.

Similar Beckmann-rearrangement of 6,7,8,9- tetrahydro-5,10-dimethyl-8-n-propyl-3-methoxy-5,8- methano-5 1;l -benzocycloheptene-7-one oxime provided l,2,3,4,5,6-hexahydro-trans-6,l l-dimethyl-2-npropyl-S-methoxy-2,6-methano-3benzazocine-4-one, m.p. 259261C. (from ethanol) and the cisdiastereoisomer lactam, m.p. 159166C. (from ethyl acetate-hexane). Both racemate pairs showed a closely related IR spectra; 2.9lp.(NH),

m": 3 6.03,u(-NH- CQ Mass spectrum showed the following major fragment-ions m/e 287 (M 272 (base), 244,230, 188, 166. i Analysis for C H- NO 287.39. requires: C,'75.22; H, 8.77; N, 4.87%. found: C, 75.34; H, 8.68; N, 4.59%.

l,2,3,4,5,6-Hexahydro-2.l l-dimethyl-6-ethyl-8- methoxy-2,6-methano-3-benzazocine-4-one, l,2,3,4,5- ,6-hexahydro-l 1-methyl-6-ethyl-2n-propyl-8- methoxy-Z,6-methano-3-benzazocine-4-one and l,2.3,- 4,5,6-hexahydro-l 1-methyl-2,6-diethyl-8-methoxy- 2,6-methano-3-benzazocine 4-one can be prepared in similar fashion. I

EXAMPLE 19 l.2,3,4,5,6-Hexahydro-2,6,l l-trimethyl-8-methoxy- 2,6-methano-3-benzazocine 17.0 g. of l,2,3,4,5,6-hexahydro-2,6,l l-trimethyl-8- meth0xy-2,6-methano-3-benzazocine-4-one was added in small portions to a slurry of 10.0 g. lithium aluminumhydride in 700 ml. of dry tetrahydrofuran. The resulting mixture was refluxed for about 14 days. After conventional workup, crude l,2,3,4,5,6-hexahydro- 2,6,1 l-trimethyl-8-methoxy-2,6-methano-3- benzazocine was obtained. The crude amine was dissolved in ether. and the ether solution treated with dry ethereal hydrochloric acid. l,2,3,4,5,6-Hexahydro- 2,6,1 l-trimethyl-8-methoxy-2,6-methano-3- benzazocine hydrochloride thus formed was recrystallized from ethanol; m.p. 272273C. (dec); A 3.5-4.0,u(secondary amine salt.)

MHZ NMR spectrum of the trans-CdC -methyl diastereoismer obtained above in CDCl /D O/KOD solution exhibited chemical shifts at 81.06 (d, 3H; C equatorial methyl protons), 81.18 (s, 3H) 81.35 (s, 3H), 83.78 (s, 3H).

100 MHz NMR spectrum of the cis-C /c -methyl isomeric amine obtained in similar fashion in CDCl /D O/KOD showed the diamagnetically shifted doublet for its C -methyl protons at 80.80 (d, 3H) and chemical shifts at 81.14 (s, 3H), 1.43 (s, 3H), 83.78 (s, 3H).

Mass spectrum of the amine possessed the following fragment ion peaks: m/e 245 (m"), 230 (base), 216, 187,174, 161.

Analysis for C H NOCI, 281.80. requires: C, 68.19; H, 8.58; N, 4.97%. found: C, 67.99; H, 8.49; N, 4.91%.

Following the above procedure, but substituting for 1,2,3,4,5,6-hexahydro-2,6,l l-trimethyl-8-methoxy- 2,6-methano-3 benzazocine-4-one an appropriate l,2,- 3,4,5,6-hexahydro-2,6,l 1-trialkyl-8-methoxy-2,6- methano-3-benzazocine-4-one, one can obtain l,2,3,4- ,5,6-hexahydro-6,l l-dimethyl-2-ethyl-8-methoxy-2,6- methano-3-benzazocine, the hydrochloride salt of which melted at 284286c.; k 'a 3.55-4.0p. (secondary amine salt).

Analysis for C H NOCl, 295.83. requires: C, 69.02; H, 8.86; N, 4.73%. found: C, 68.81; H, 8.67; N, 4.70%. l,2,3,4,5,6-Hexahydro-6,l l-dimethyl-2-n-propyl-8- methoxy-2,6-methano-3-benzazocine was prepared in similar fashion and isolated as its hydrobromide salt;

m.p. 238.5-240.5C.

Similarly, 1.2,3,4,5,6-hexahydro-2.l 1-dimethyl-6- ethyl-8-methoxy-2,6-methano-3-benzazocine and 1,2.- 3,4,5,6-hexahydro-1 l-methyl-2,6-diethyl-8-methoxy- 2,6-methano-3-benzazocine were prepared.

EXAMPLE 20 1,2,3,4,5,6-Hexahydro-2,6,1 l-trimethyl-2,6-methano- 3-benzazocine-8-ol Ten grams of 1,2,3,4,5,6-hexahydro-2,6,l 1- trimethyl-8-methoxy-2,6-methano-3-benzazocine hydrochloride were melted in an oil bath with 40 g. of pyridinium hydrochloride at a temperature in the range 185C. for 16 hours. The reaction mixture was cooled and dissolved in water. The aqueous solution was made alkaline by the addition of, ammonium hydroxide at 0C., and the base insoluble material extracted into chloroform. The chloroform layer was separated and evaporated to dryness. The resulting residue was triturated with ether. l,2,3,4,5,6-hexahydro- 2,6,1 l-trimethyl-2,6-methano-3-benzazocine-8-ol thus obtained crystallized and was separated by filtration; m.p. 235237C. lt,,,,,," 3.05 2, 4.0a; NMR (DMSO-d 80.70 ((1, 3H), 81.07 (s, 3H), 81.28 (s, 3H).

Mass spectrum exhibited the following fragmentation pattern: m/e 231 (M*), 216 (base), 202, 186, 173, 160-, 145, 124. y

Analysis for C H NO, 231.34. requires: C, 77.88; H, 9.15; N, 6.05%. found: C, 77.54; H, 8.96; N, 5.86%. tHH

Following the above procedure, but substituting for 1,2,3,4,5,6-hexahydro-2,6,1 ltrimethyl-8-methoxy 2,6-methano-3-benzazocine an appropriate 1,2.3,4,5,- 6-hexahydro-2,6,1 l-trialkyl-8-methoxy2,6-methano- 3-benzazocine, one can obtain l,2,3,4,5,6-hexahydro- 6,1 1-dimethyl-2-ethyl-2,6methano-3-benzazocine-8- o1; m.p.=238-243C. (from ethanol) and 1,2,3,4,5,6- hexahydro6,l 1-climethyl- 2-n-propyl-2,6-rnethano-3- benzazocine-S-ol; m.p. 17981C (isopropanol).

1.2,3,4,5,6-Hexahydro-2,1 l-dimethyl-6-ethyl-2,6- methano-3-benzazocine-8-ol and hexahydro-l 1-methyl-2,6-diethyl-2,6-methano-3-benzazocine-8-ol can also can be obtained by the above procedure.

EXAMPLE 21 1,2,3,4,5,6-Hexahydro-3-( 3-methyl-2 butenyl)-2,6,1 1- trimethyl-2,6-methano3-benzazocine-8-ol A mixture of 5.2 g. of l,2,3,4,5,6-hexahydro-2,6,1 1- trimethyl-2,6-methano-3-benzazocine-8-ol, 2.1 g. of NaHCO and 2.6 g. of 1-ch1oro-3-methy1-2-butene was refluxed in 250 ml. of dimethylformamide for 4 hours. The reaction mixture was evaporated to dryness and the resulting residue was extracted with ether. The ethereal extract was separated and upon treatment with dry ethereal hydrogen bromide yielded 5.2 g. of 1,2,3,- 4,5,6-hexahydro-3-(3-methyl-2-butenyl)-2,6,1 1- trimethy1-2,6-methano-3-benzazocine-8-01 hydrobromide which was recrystallized from isopropanobether. Purified 1,2,3,4,5,6-hexahydro-3-( 3-methyl-2- butenyl )-2,6,1 1 -trimethy1-2,6-methano-3-benzazocine- 8-01 hydrobromide melted at 228-228.5C. (dec) (from i-propanol). Its mass spectrum exhibited a inolecular ion (M 299) and the following major fragment Analysis for C H ON .HBr, 380.35. required: C, 63.16; H, 7.94; N, 3.68%. found: C, 63.00; H, 8.08; H, 3.52%.

In order to achieve a better water solubility the above hydrogen bromide salt was transformed into the lactate salt by conventional methods. Purified 1,2,3,4,5,6- hexahydro-3-( 3-methyl-2-butenyl)-2,6,1 l-trimethyl- 2,6-methano-3-benzazocine-8-o1 lactate melted at 184185C.

Following the above procedure but substituting for 1,2,3,4,5,6-hexahydro-2,6,1 1-trimethyl-2,6-methano- H, 9.42; N, 3.85%. found: C 72.86; H, 9.62; N, 3.63%.

Catalytic reduction of 1,2,3,4,5,6-hexahydro-3-(3- methyl-2-butenyl)-6,1 1-dimethyl-2-n-propyl-2,6- methano-3-benzazocine-8-o1 led to 1,2,3,4,5,6- hexahydro-3-(3-methylbutyl)-6,1 l-dimethyl-Z-npropy1-2,6-methano-3-benzazocine-8-o1, isolated as its hydrochloride salt: m.p. 322324C. (from water); d-lactate salt: m.p. 2723C. (dec.) (from isopropanol).

1,2,3,4,5,6-Hexahydro-3-(3methyl-2-butenyl)-2,l 1- dimethyl-6-ethyl-2,6-methano-3-benzazocine-8-ol and 1,2,3,4,5,6-hexahydro-3-(3-methyl-2-butenyl)-1 lmethyl-2,6-diethyl-2,6-methano-3-benzazocine-8-ol can be prepared in similar fashion.

Following the above procedure but substituting allyl bromide for 1-chloro-3-methyl-2-butene, one can obtan l,2,3,4,5,6-hexahydro-3-a11yl-2,6,1 l-trimethyl- 2,6-methano-3-benzazocine-8-ol, m.p.=l978C. 100 MHZ NMR spectrum in CDCl,; shows chemical shifts at 80.83 (d, 3H; C1-1 C 1;1 51.23 (s, 3H, c g i,, 61.35 (s, 3H; CQ 3), 85.04 (m, 2H; CH=C 1- 1 Mass spectrum showed the following major fragment ions: m/e 271 (M*), 256 (base), 242, 230. 214, 187, 164, 136 and 124.

Analysis for C H NO, 271.39. requires: C, 79.66; H, 9.29; N, 5.16%. found: C, 79.42; H, 9.03; N, 5.09%.

Hydrogen bromide salt of 1,2,3,4,5,6-hexahydro-3- allyl-2,6,1 1-trimethyl-2,6-methano-3-benza2ocine-8-ol melted at 245C. (dec).

Analysis for C H NQBr, 352.32. requires: C, 61.36; H, 7.44; N, 3.98%. found: C, 61.46; H, 7.47; N,

1,2,3,4,5,6-Hexahydro-3-allyl-6,1 1-dimethy1-2-ethy1- 2,6-methano-3-benzazocine-8-ol was obtained in similar fashion and isolated as hydrochloride salt; m.p.=237239C. (dec); h,,,,,,'"= 320p. (OH), 3.8; (salt). 100 MHz NMR spectrum in DMSO-d, exhibited chemical shifts at 80.73 (d, 3H; CH C 1- l 81.03 (t, 3H; -CH --CH 81.33 (s, 3H; C-CH 86.25 (m. 1H; -CH=CH 86.75 (m, 2H; -CH=CH 89.4 (OH), 810.17

Mass spectrum possessed the following major fragment ions: m/e 285, 270, 256, 178.

Mass spectrum exhibited the following fragmentation pattern m/e 299 (M*), 284, 256 (base), 192.

Analysis for C H NOCI, 321.86. requires: C, 70.90; H, 8.77; N, 4.35%. found: C, 70.65; H. 8.84; N, 4.25%.

Similarly 1,2,3,4,5,6-hexahydro-3-allyl-6,1 1-

dimethyl-2-n-propyl-2,6-methano-3-benzazocine-8-ol hexahydro-3 a1ly1-1 l-methy1-2,6-diethyl-2,6-methano- 3-benzazocine-8-ol can be synthesized by the above procedure.

The above procedure can also be used to prepare the 3-phenethyl derivatives of the 1,2,3,4,5,6-hexahydro- 2,6,11-trialkyl (and 6,11-dialkyl)-2,6-methano-3-benzazocine-8-ols of the corresponding 8-alkoxy derivatives as furnished by Examples 1920.

EXAMPLE 22 1,2,3,4,5,6-Hexahydro-3-(cyclopropylmethyl)-2,6,1 1- trimethyl-2,6-methano-3-benzazocine-8-ol Six grams of 1,2,3,4,5,6-hexahydro-2,6,1 l-trimethyl- 2,6-methano-3-benzazocine-8-ol were suspended in 260 ml. of dichloromethane and treated with 45 ml. of triethylamine. To the stirred suspension, 6.8 g. (2.5 mole excess) of freshly distilled cyclopropylcarbonylchloride were added. The reaction mixture became homogeneous and was heated to reflux temperature for about 18 hrs. U

The mixture was cooled and extracted with 10% hydrochloric acid at C. The organic layer was dried and filtered. Evaporation yielded a pale yellow gum com prising the -N,O-di-cyclopropylcarbonyl derivative A,,,,,,"" 5.73p.(-O-- I Q), 6.15p. N-QQ).

The crude ester-amide mixture was reduced :by refluxing for 6 hours with 2.0 g. of LiAlH, in THF. The reaction mixture was cooled, diluted with ether and decomposed by icewater. After filtration to remove the solids, evaporation of the filtrate yielded the free base of l,2,3,4,5,6-hexahydro-3-(cyclopropylmethyl)- 2,6,1 1-trimethyl-2,6-methano-3-benzazocine-8-ol m.p.=177177.5C. (CHCl-Jhexane). 60 MHz NMR spectrum in CDCL, exhibited chemical shifts at 80.48 (m, cyclopropyl ring protons), 80.81 (d, 3H, CH- C H 81.22 (s, 3H; C-Q ll 81.32 (s, 3H; C-CH 86.7 (m, 3H, aromatic protons). Mass spectrum showed the following fragmentation pattern: m/e 285 (M*), 270 (base), 256, 244, 230, 216, 201, 187, 178, 172, 164, 159, 150 and 138.

Analysis for C H NO, 285.41. requires: C, 79.95; H, 9.54; N, 4.91%. found: c, 80.01; H.- 9:84; 141497 7..

Following the above procedure but substituting for 1,2,3 ,4,5,6-hexahydro-2,6,1 l-trimethyl-2,6-methano- 3-benzazocine-8-ol, 1,2,3,4,5,6-hexahydro-6,'1 1- dimethyl-2-ethyl-2,6-methano-3-benzazocine-8-ol, the N,O-dicyclopropylcarbonyl intermediate was isolated. m.p.=l30130.5C. (hexane); 5.7%,1 ;9- 6.2 11 N- Q Analysis for C- H NO, 381.50. requires: C, 75.56; H, 8.19; N, 3.67%. found: C, 75.78; H, 8.10; N, 3.89%.

A selective LiAlH, reduction of the N,O-dicyclopropylcarbonyl intermediate at room temperature gave rise to 1,2,3,4,5,6-hexahydro-3-cyclopropylcarbony1- 6,1 1-dimethyl-2-ethyl-2,6-methano-3-benzazocine-8- o1; m.p.=220-222C.; 3.1;.4. (OH); 6.25;. NC O-).

Mass spectrum of the N-cyclopropylcarbonyl derivative exhibited the following fragmentation pattermm/e 313 (M*), 298, 284, 244, 230, 213, 202, 187, 173 (base).

Analysis for C H NO, 313.42. requires: C, 76.64; H, 8.68; N, 4.47%. found: C, 76.88; H, 8.44; N, 4.56%.

Finally, LiAlH, reduction of the N,O-diacy1 or N- acyl derivatives in refluxing tetrahydrofuran solution led'to 1,2,3,4.5,6-hexahydro-3-(cyclopropylmethyl)-6,1 1- dimethyl-2-ethyl-2,6-methano-3-benzazocine-8-ol which was isolated as the hydrochloride salt; m.p.=247250C. (dec); ,u.,,,,,,""' 2.9512, 3,20,u., 3.45 3.70-3.80 (salt). Mass spectrum showed the following major fragment ions: m/e 299 (M*), 284 (base), 270, 230, 192.

"Analysis for C ,H;,,.,NOC1, 335.89. requires: C, 71.51; H,'9.00;' N, 4.17%. found: C, 71.28; H, 9.29; N, 4.41%.

Similarly l,2,3,4,5-hexahydro-'3- (cyclopropylmethyl)-6,1 l-dimethyl-2-propy1-2,6- methano-3-ben2azocine-8-ol hydrochloride was prepared; m.p. 27l273C. (from ethanol-water). Mass spectrum showed the following fragmentations rn/e 313(M), 298, 284, 270 (base), 206, 178, 173. Analysis for C H 'NQCl, 349.94. requires: C, 72.08; H, 9.22; N," 4.00%. found: C, 72.23; H, 8.96; N, 4.00%. 1,2 ,3,4,5,6-Hexahydro-3-( cyclopropylmethyl )-2,1 1- dimethyl 6-ethyl-2,6-methano'3-benzaz0cine-8-0l and l,2,3,4,5,6-hexahydro-3-(cyclopropylmethyl)-2,6- diethyl-l 1-methyl-2,6-methano-3-benzazocine-8-ol can be synthesized in the sameway.

EXAMPLE 23 1,2,3,4,5,6-Hexahydro-2-( 3-methyl-2-butenyl)-2,6,1 ltrimeth'yl-8-methoxy-2,6-methano-3-benzazocine Following the procedure of Example 22, but substituting for the aminophenol starting material an equivalent amount of 1 ,2,3,4,5,6-hexahydro-2,6,1 l-trimethyl- 8-methoxy-2,6-methano-3-benzazocine from Example 19, 1,2, 3,4,5,6-hexahydro-3-(3-methyl-2-butenyl)- 2,6,1 1-trimethyl-8-methoxy-2,6-methano-3- benzazocine was prepared. The product was isolated at its hydrochloride salt; m.p.=l99200.5C. (dec), (from i-propanol/hexane); 3.95}; (broad, -amine salt). NMR spectrum in C DCl solution exhibited chemical shifts at 80.94 (d, 3H; CHC |j 81.50 (s, 3H; C-C H 81.68 (s, 3H; C=Q l;! 81.78 (s, 6H; C(C ll );.83.82 (s, 3H; Q (ll -l,,).

Mass spectrum exhibited the following major fragment peaks: m/e 313 (M*), 298 (base), 284, 258, 245, 230,192, 174, 124, 113.

Following the same procedure but utilizing an equimolar amount of 1 ,2 ,3,4,5,6-hexahydro-6-,1 l-dimethyl- 2-ethyl 8 methoxy-2,6-methano-3-benzazocine from Example 19, l,2,3,4,5,6-hexah'ydro 3-(3-methyl-2- butenyl -6,1 1-dimethyl-2-ethy1-8-methoxy-2,6- methano-3 -benza-zocine' was prepared. lts hydrochloride salt-was crystallized from ethanol-ether and melted at 172-174C. (dec); u,,,,,,""': 4.0;]. (tertiary amine salt). N

Mass spectrum showed the following pattern: m/e 327 (M*), 312, 298, 259,- 244, 230.

Analysis for C H NOCI, 363.97. requires: C, 72.60; H, 9.42; N, 3.85%. found: C, 72.84; H, 9.44; N, 3.86%

Following the same procedure but utilizing'an equimolar amount of -1,2,3,4,5,6-hexahydro-6,1 l-dirnethyl- 2-n-propyl-8-methoxy-2,6-methano3-benzazocine from Example 19, 1,2,3,4,5,6-hexahydro-3-(3-methyl 2-butenyl )-6,1 1-dimethyl 2-n-propyl-8-methoxy-2,6- methano-3-benzazocine hydrobromide was obtained; m.p. 153l54.5C. (from ethanol-water);

Similarly butenyl )-2,1 1-dimethyl-6-ethyl-8-methoxy-2,6- methano-3-benzazocine and l,2,3,4,5,6-hexahydro-3- (3-methyl-2-butenyl)-1 l-methyl-2,6-diethyl-8- methoxy-2,6-methano-3-benzazocine can be prepared.

EXAMPLE 24 1,2,3 ,4,5 ,6-Hexahydro-3-allyl-2,6,1 1-trimethyl-8- methoxy-2,6-methano-3-benzazocine A mixture of 1.40 g. of 1,2,3,4,5,6-hexahydro-2,6,l 1- trimethyl- 8-methoxy-2,6-methano-3-benzazocine drochloride from Example 19, 1.26 g. of NaHCO and 0.66 g. of allylbromide was refluxed in 25 ml. dimethyl- 1,2.3,4,5,6-hexahydro-3-(3 methyl-2- formamide for 5 hours. The reaction mixture was evaporated to dryness, and the resulting oily residue was chromatographed over A1 (neutral). l,2,3,4,5,6- l-lexahydro-3-allyl-2,6,l l-trimethyl-8-methoxy-2.6- methano-3-benzazocine was eluted by benzene. lts hydrobromide salt was recrystallized from ethanol/ether and melted at 222226C. (dec); ;1.,,,,,,' 4.0;; (tertiary amine salt). Mass spectrum of the N-allylbenzazocine derivative exhibited the following fragmentation pattern: m/e 285 (M*), 270 (base), 256, 201, 174, 1164.

Analysis for C H NOBr, 366.34. requires: C, 62.29; H, 7.70; N, 3.82%. found: C, 62,08; H, 7.86; N, 3.87%.

l,2,3,4,5,6-1-lexahydro-3-allyl-6-,l l-dimethyl-2- ethyl-8-meth0xy-2,6-methano-3-benzazocine, l,2,3,4,- 5,6-hexahydro-3allyl-6,l l-dimethyl-2-n-propyl-8- methoxy-2,6-rnethano3-benza2ocine, 1,2,3,4,5 ,6- hexahydro-3-allyl-2,l l-dimethyl-6-ethyl-8-methoxy- 2,6-methano-3-ben2azocine and 1,2,3,4,5,6- hexahydro-3-allyl-l l'rnethyl-2,6-diethyl-8-methoxy- 2,6-methanobenzazocine can be synthesized in similar fashion.

EXAMPLE 25 1,2,3,4,5 ,6-l-lexahydro-3-(cyclopropylmethyl)-2,6,l l trimethyl- 8-methoxy-2,6-methano-3 -benzazocine To a solution of 1.0 g. of l,2,3,4,5.6-hexahydro- 2,6,1 1-trimethyl-8-methoxy-2,6-methano-3- benzazocine hydrochloride in 50 ml. of CH CL and ml. of Et N, were added 0.92 g. of cyclopropylcarbonylchloride. The reaction mixture was refluxed for 16 hours, and then cooled. The resulting solution was extracted with hydrochloric acid at 0C. The organic layer was separated. After the evaporation of the solvent therefrom, an oil was obtained which solidified upon standing. Recrystallization from ethanol yielded the expected N-cyclopropylcarbonyl derivative; m.p.=l28.5l30C; h a 6.18 1. NC I Q); NMR (CDCl 50.56 (m, 4H; cyclopropyl protons)", 0.86 (d, 3H; CH-C l-1 51.38 (s, 3H; C-Cfl 51.61 (s, 3H; C-QH 53.50 (t, 1H), 53.78 (s, 3H; Q Ha)- Mass spectrum possessed the following major fragment ions: m/e 313 (Mi base), 298, 244, 226, 213, 201, 186.

Analysis for C H NO 313.44. requires: C, 76.64; H, 8.68; N, 4.47%. found: C, 76.41; H, 8.92; N, 4.37%.

The crude N-cyclopropylcarbonyl benzazocine derivative was then reduced by LiAlH, in tetrahydrofuran at room temperature. After the reaction mixture was worked up by conventional methods, l,2,3,4,5,6- hexahydro-3-(cyclopropylmethyl)-2,6,1 1-trimethyl-8- methoxy-Z.,6-methano-3-benzazocine was obtained in quantitative yield. The free base was transformed into the hydrobromide salt which was recrystallized from i-propanol/hexane; m.p.=242.5243C. (dec); NMR CDCl /DMSO-d exhibited chemical shifts for the protons of the cyclopropyl ring at 50.56 (m, 5H) and 50.94 (d, 3H; CHQ H 51.50 (s, 3H; C( l;l 51.70 (s, 3H; CQ l;1 53.81 (s, 3H; -Q(l Mass spectrum showed the following major fragment ions: m/e 229 (MU, 284,270, 258, 201, 178.

Analysis for C H NOBr, 380.35. requires: C, 63.15; H, 7.95; N, 3.68%. found: C, 62.97; H, 8.20; N, 3.44%.

Following the above procedure, but substituting for the benzazocine secondary amine component an equimolar amount of l,2,3,4,5,6hexahydro-6,1 l-dimethyl- 2-ethyl-8-methoxy-2,6-methano3benzazocine, one obtains l,2,3,4,5,6-hexahydro-3-(cyclopropylmethyl)- 6,1 l-dimethyl-2-ethyl-8-methoxy-2,6-methano-3- benzazocine isolated as the hydrochloride salt which, after recrystallization from ethanol/ether, melted at 237238C. (dec); )t f 'a 4.05;). (tertiary amine salt). Mass spectrum showed the following major peaks: m/e 313 (M*), 298, 284, 258, 192.

Analysis for C H NQCI, 349.94, requires: C, 72.08; H, 9.22; N, 4.00%. found: C, 71.88; H, 8.97; N, 3.91%.

Using a similar procedure, l,2,3,4,5,6-hexahydro-3- (cyclopropylmethyl )-6,l 1-dimethyl-2-npropyl-8- methoxy-2,6-methano-3-benzazocine, l,2,3,4,5,6- hexahydro-3( cyclopropylmethyl)-2,1 l-dimethyl-6- ethyl-8-methoxy-2,6methano3-benzazocine and 1,2,- 3,4,5,6-hexahydro-3-(cyclopropylmethyl )-l l-methyl- 2,6-diethyl-8-methoxy-2,6-methano-3-benzazocine can be synthesized.

EXAMPLE 26 Preparation of Salts Salts of the free bases of this invention, other than the hydrochloride or hydrobromide salts whose preparation is illustrated in the above examples, are prepared by dissolving the free base in ether and adding an equivalent of a suitable non-toxic acid, also in ether. The salts thus formed, as for example the sulfate and phosphate salts, are insoluble in ether and can be iso lated by filtration. Alternatively, the amine base can be dissolved in ethanol and an equivalent of the acid added as an ethanolic solution. In this instance, since a majority of the salts thus formed are soluble in the re action mixture, they are isolated by addition of ether or by evaporation of the solvent in vacuo. Purification is usually by recrystallization. Salts which can be formed by the above procedure include the sulfate, phosphate, hydrogen phosphate, dihydrogen phosphate, acetate, maleate, fumarate succinate, tartrate, citrate, lactate, benzoate, methane sulfonate and p-toluene sulfonate salts of the novel benzazocines of this invention.

As previously stated, the compounds ofthis invention according to formula I wherein R is other than hydrogen are analgetics, analgetic antagonists or are analgetics having a degree of antagonist activity, similar to pentazocine, For example, l,2,3,4,5,6-hexahydro- 2,6,1 l-trimethyl3-(3-methyl-2-butenyl)2,6-methano- 3-benzazocine-8-ol is a pure analgetic, more powerful than pentazocine but without analgetic antagonist activity. The corresponding 3-allyl derivative is an analgetic with some antagonist activity, as is the corresponding 3-cyclopropylmethyl derivative. The 8- methyl ethers of the above three compounds are also analgetically active substances, though not as active as the benzazocine-8-ols themselves. The higher homo logues, the l,2,3,4,5,6-hexahydro 2-ethyl (or 2- propyl)-6,l 1-dimethyl-3-substituted-2,6-methano-3- benzazocine-8-ols and the corresponding 8-methoxy ethers are also active analgetics, with those derivatives having a free phenolic group at 8 being particularly active. For example, both a-dl and Bdl l,2,3,4,5,6- hexahydro-2-ethyl-6,l 1-dimethy1-3-allyl-2,6-methano- 3-benzazocine-8-ol are analgetically active as are a-dl and B-dl l,2,3,4,5,6-hexahydro-2-ethyl-6,l l-dimethyl- 3-(3-methyl-2-butenyl)8-methoxy-2,6-methano-3- benzazocine. The corresponding 3-cyclopropylmethyl derivatives, including both the a-dl and [3 -dl racemic pairs, are also analgetics. Likewise compounds in which the substituent on the 2-position of the benzazocine ring is propyl are active analgetics.

The compounds of this invention may be administered to mammals to produce analgesia or narcotic antagonism either parenterally or orally. Pharmaceutical formulations for the administration of the compounds of this invention to mammals include the use of solid pharmaceutical forms such as tablets and pulvules or in liquid forms including solutions, suspensions or emulsions. Suitable liquid and solid carriers including water, gelatin, lactose, starch, talc, vegetable oils, alcohols, polyalcohols, gums, syrups and the like can be used. The pharmaceutical composition in addition to the active principle and carrier, may include auxiliary materials such as coloring or stabilizing agents, or wetting or emulsifying agents. It is, of course, recognized that the carrier as well as any other materials present, must be chemically and physiologically inert with respect to the active principle.

When the pharmaceutical preparation is compounded in the manner suggested above, it will contain an amount of from about -500 mg/ml of the vehicle of the analgesic substance. When so prepared, the novel compounds of this invention may be administered in therapeutic dosages of from about 1020O mg/day to a mammal.

I claim:

1. A substituted benzazocine of the formula alk C. N-R

alk

R'O t 2 wherein each alk is independently C -C alkyl, R is H or alk and R is H, alk or -cH-R wherein R is cyclopropyl or C C,,- alkenyl and R is hydrogen, methyl or ethyl, the sum of the carbon atoms in R plus R being less than 7; and pharmaceuticallyacceptable acid addition salts thereof formed with nontoxic acids.

2. A compound according to claim 1, said compound being l,2,3,4,5,6-hexahydro-2,6,l l-trimethyl-3-(3- methyl-Z-butenyl)-2,6-methano-3-benzazocine-8-ol.

3. A compound according to claim 1, said compound being l,2,3,4,5.6-hexahydro-2,6,l l-trimethyl-3-allyl- 2,6-methano-3-benzazocine-8-ol. I

4. A compound according to claim 1, said compound being l,2,3,4,5,6-hexahydro-2,6,l l-trimethyl-3 cyclopropylmethyl-2,6-methano-3-benzazocine-8-ol.

5. A compound according to claim 1, said compound being l,2,3,4,5,6-hexahydro-2-ethyl-6,l 1-dimethyl-3- (3-methyl-2-butenyl)-2,6-methano-3-benzazocine-8- 01.

alk al lyl aIkO wherein Q is H or alk and each alk is independently C -C alkyl;

and hydrolyzing the resulting ozonide to form a oz-ketoaldehyde of the formula CH -CH0 wherein alk and Q have the same meaning as hereinabove; treating said a-ketoaldehyde with alkali, to form via an intramolecular aldol condensation, a methanobenzocycloheptenolone of the formula .o alkO I,

alk

wherein alk and Q have the same meaning as hereinabove; forming a tetrahydropyranyl ether of the resulting benzocycloheptenol, reacting the thus formed ether with a lower alkyl phosphonium ylide, and then hydrolyzing the tetrahydropyranyl group to produce a benzocycloheptenol of the formula wherein Q and alk have the same meaning as hereinabove and R is H methyl or ethyl;

oxidizing the hydroxyl function to a ketone group and reducing the olefinic linkage to yield a benzocycloheptenone of the formula alkO I wherein Q and alk have the same meaning as hereinabove;

converting the ketone group to an oximino group by reaction with a salt of hydroxylamine and rearranging the oxime to yield a cyclic lactam of the formula alO wherein Q and alk have the same meaning as hereinabove; alkylating said benzazocine with a phenethyl halide (C H CH -CH X) or with an alkyl halide of the following formula 30 wherein X is a halogen, R is cyclopropyl or C -C alkenyl, and R is H, methyl or ethyl, the sum of the carbon atoms in R and R being less than seven or by a cyclopropyl carbonyl halide followed by a reduction of the carbonyl group to a methylene group to yield an N- alkyl benzazocine of the formula HC--a l wherein Q and alk have the same meaning as hereinabove and R is phenethyl or wherein R is cyclopropyl or C -C alkenyl and R is H, methyl or ethyl, the sum of the carbon atoms in R and R being less than seven.

and then hydrolyzing the phenolic ether group with strong acid to yield a benzazocine of the formula N-R HC-al alk wherein alk, Q and R have the same meaning as here- 

1. A SUBSTITUTED BENZAZOCINE OF THE FORMULA
 2. A compound according to claim 1, said compound being 1,2,3,4, 5,6-hexahydro-2,6,11-trimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3 -benzazocine-8-ol.
 3. A compound according to claim 1, said compound being 1,2,3,4, 5,6-hexahydro-2,6,11-trimethyl-3-allyl-2,6-methano-3-benzazocine-8-ol.
 4. A compound according to claim 1, said compound being 1,2,3,4, 5,6-hexahydro-2,6,11-trimethyl-3-cyclopropylmethyl-2,6-methano-3-benzazocine-8-ol.
 5. A compound according to claim 1, said compound being 1,2,3,4, 5,6-hexahydro-2-ethyl-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3 -benzazocine-8-ol.
 6. A compound according to claim 1, said compound being 1,2,3,4, 5,6-hexahydro-2-ethyl-6,11-dimethyl-3-allyl-2,6-methano-3-benzazocine-8-ol.
 7. A compound according to claim 1, said compound being 1,2,3,4, 5,6-hexahydro-2-ethyl-6,11-dimethyl-3-cyclopropylmethyl-2,6-methano-3 -benzazocine-8-ol.
 8. A compound according to claim 1, said compound being 1,2,3,4, 5,6-hexahydro-2-n-propyl-6,11-dimethyl-3-(3-methyl-2-butenyl)-2, 6-methano-3-benzazocine-8-ol.
 9. The process of preparing substituted benzazocines which comprises ozonizing an allyl tetralone of the formula 